Activating TRPML1 for uranium-induced nephrotoxicity

Activating the calcium channel TRPML1, which regulates lysosomal exocytosis, could help treat nephrotoxicty caused by uranium exposure by protecting kidney cells from lysosomal-dependent cell death.

In uranium-exposed mice, administration of a TRPML1 agonist tool compound 24 hours or five days after exposure lowered uranium levels in the kidney while increasing uranium levels in the urine, and decreased proximal tubule pathology and kidney cell apoptosis compared with vehicle. In mice treated after 24 hours, the compound also decreased kidney injury markers including serum creatinine and blood urea nitrogen. ...