Inhibiting a circular RNA-encoded MET variant for glioblastoma

Inhibition of MET404, a MET variant encoded by m6A-modified circular RNA that induces constitutively active MET signaling, could help treat glioblastoma (GBM) by decreasing GBM stem cell self-renewal, invasiveness and tumorigenicity. 

RNA-sequencing and immunoprecipitation analyses to identify m6A-modified, translatable circular RNAs in patient GBM samples identified circMET, which encodes MET404. In GBM patient tumor samples, high protein expression of MET404 was associated with lower overall survival than low MET404 expression. ...