A single-dose intranasal VRP vaccine for Nipah virus

A nasally delivered Nipah virus replicon particle (VRP) vaccine lacking the fusion protein gene required for viral spreading between cells could help prevent Nipah virus infection by increasing Fc-dependent antibody effector functions.

In a mouse model of Nipah virus infection, a single prophylactic intraperitoneal immunization with the VRP vaccine up to three days prior to infection increased survival and decreased body weight loss, clinical signs of infection, and viral load in tissues compared with vehicle. ...