Targeting AHCY for APC-deficient CRC

Targeting AHCY, a MYC-regulated hydrolase involved in metabolism of the amino acid methionine, could help treat APC-deficient colorectal cancers (CRCs), which have elevated MYC expression, by decreasing protein synthesis. 

Metabolomic profiling of mouse colon tissue via untargeted mass spectrometry identified increased methionine metabolism in tumor tissues from two APC-deficient genetic mouse models of CRC compared with cancerous and non-cancerous colon tissues from mice with normal APC expression, and AHCY mRNA and protein levels were higher in APC-deficient tumor tissues than in colon tissue from mice without tumors. ...