ARTICLE | Distillery Therapeutics
Strategies to inhibit KIM1-mediated cell death for acute kidney injury
September 14, 2023 5:55 PM UTC
Compounds that block expression or signaling of the glycoprotein KIM1, which is upregulated during acute kidney injury, could help treat the condition.
Analyses of transcription factor prediction databases, renal protein expression in the Human Protein Atlas, gene expression changes in a mouse model of acute kidney injury, and cell-based assays identified the transcription factor YY1 as a regulator of KIM1 expression. ...