Inhibiting cis P-tau for preeclampsia

Inhibiting cis P-tau 231, the pathogenic cis conformation of a phosphorylated form of tau protein and a precursor for tauopathy, could help treat preeclampsia by rescuing trophoblast invasion and endovascular activity.

Levels of total cis P-tau and the insoluble protein aggregate form of cis P-tau protein were higher in the placental tissue of early- and late-onset preeclampsia patients than in samples from healthy pregnant individuals, and cis P-tau protein aggregate levels in placental trophoblast cells were higher in early onset preeclampsia patients than in healthy individuals. ...