Inhibition of calprotectin for vascular calcification in chronic kidney disease

Inhibition of calprotectin, a circulating damage-associated molecular pattern protein, could help treat vascular calcification in chronic kidney disease by blocking calprotectin-induced activation of TLR4 and RAGE.

Levels of calprotectin subunits S100A8 and S100A9 and total calprotectin protein were higher in the serum of chronic kidney disease patients who developed cardiovascular complications than in serum from patients without cardiovascular complications, and were associated with increased levels of vascular calcification. ...