Targeting a mitochondrial STAT3 complex for lung cancer

Targeting STAT3-LRPPRC-SLIRP, a mitochondrial complex that promotes mitochondrial mRNA stability and translation, could help treat lung cancer by decreasing mitochondrial energy production in tumor cells  

Immunoprecipitation-mass spectrometry in a human lung cancer cell line identified the mitochondrial protein LRPPRC and the RNA-binding protein SLIRP as mitochondrial STAT3 interactors, and in tissue microarrays of early-stage resected lung cancer biopsies, STAT3, LRPPRC, and SLIRP protein expression was higher than in matched healthy tissue...