Targeting SCARB2 for hepatocellular carcinoma

Targeting SCARB2, a phospholipid scavenger receptor involved in lysosomal cholesterol export, could help treat hepatocellular carcinoma (HCC) by disrupting acetylation of the oncogenic transcription factor MYC and its downstream transcriptional activity.  

In a human HCC cell line, a CRISPR/Cas9 loss-of-function screen using a metabolic gene library identified SCARB2 as a promoter of tumorsphere formation.  ...