Overexpressing hepatocyte TRIM26 for NASH

Overexpressing the E3 ubiquitin ligase TRIM26 in hepatocytes could help treat NASH by inducing the ubiquitination and degradation of the steatosis- and inflammation-promoting transcription factor CEBPD in hepatocytes.

TRIM26 mRNA and protein levels were lower in liver samples from NASH patients and from mice fed a high-fat high-cholesterol diet than in samples from non-steatosis patients and mice fed a normal diet, respectively. ...