ARTICLE | Distillery Therapeutics
CHK2 inhibition for Type II diabetes
December 20, 2023 10:53 PM UTC
Inhibiting the DNA damage repair regulator CHK2 could help treat Type II diabetes by relieving inhibition of the kinase PLK1, and thus promoting activation of the pentose phosphate pathway, which increases insulin secretion and glucose tolerance.
In a mouse pancreatic β cell line exposed to glucose, a chemical screen of small molecules that acutely enhanced insulin secretion identified a competitive dual CHK1/CHK2 inhibitor tool compound as a top hit. ...