Intranasal S. pyogenes vaccine
An adjuvanted, intranasal, liposomal peptide vaccine delivering a cryptic Streptococcus pyogenes antigen could help prevent infection by activating Th17 cells while avoiding autoimmune molecular mimicry.
The vaccine comprised liposomes containing a cryptic peptide from the C3-repeat region of the S. pyogenes M protein, and was adjuvanted by a TLR4 ligand and diptheria toxoid. ...
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