ARTICLE | Distillery Therapeutics
Epstein-Barr virus gB nanoparticle vaccine
January 18, 2024 12:58 AM UTC
A protein nanoparticle vaccine displaying the viral membrane fusion protein gB could help prevent EBV by increasing gB protein stability and antigenicity to host neutralizing antibodies.
In mice, vaccination with a trimeric protein nanoparticle composed of a computationally designed core peptide, a flexible linker, and gB protein increased antibody titers in a dose-dependent manner compared with gB protein alone, and further increased antibody titers when combined with an CD4+ T cell-stimulating adjuvant...