Inhibiting CHI3L1 for triple-negative breast cancer

Inhibiting the cytokine CHI3L1 could help treat the stromal-restricted subtype of triple-negative breast cancer (TNBC) by preventing neutrophil recruitment and neutrophil extracellular trap formation in mammary glands, thus increasing T cell infiltration into tumors.

In bioinformatic analyses of The Cancer Genome Atlas data, CHI3L1 expression was higher in basal-like breast cancer than HER2-positive, Luminal A or Luminal B breast cancers, and higher CHIL3L1 expression correlated with reduced survival. ...