Inhibition for TRPC6 for triple negative breast cancer

Inhibiting TRPC6, a cation channel that promotes calcium entry, could help treat triple negative breast cancer (TNBC) by relieving repression of a splice variant of the integrin VLA-6, whose signaling represses the oncogene MYC, thus decreasing cancer cell stemness and resistance to chemotherapy.

RNA-sequencing of human mammary epithelial cell lines, before and after oncogenic transformation, identified TRPC6 mRNA as highly expressed in the transformed cells relative to paired non-transformed cells. ...