HFE2 for blood-brain barrier integrity in MS

Treatment with the liver-derived, lipid-anchored protein HFE2 could help promote blood-brain barrier integrity in MS patients by blocking the leak-inducing effects of its homologue RGMA, whose relevance in MS was previously established by human genomic and mouse studies.

In mouse endothelial cells exposed to RGMA, soluble HFE2 reversed RGMA-induced changes in the expression of blood-brain barrier integrity regulators including PDGFRB, HIF1A, and CLDN5 compared with vehicle. ...