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ARTICLE | Distillery Therapeutics

Inhibiting inceptor for hyperglycemia in obesity

BC Staff
March 26, 2024 7:56 PM UTC

Inhibiting the transmembrane receptor inceptor could help treat obesity by decreasing insulin signaling desensitization via clathrin-mediated endocytosis of the insulin receptor and IGFR1 complex, thus improving glucose homeostasis.

Inceptor mRNA and protein expression levels were higher in the hypothalamus of mice fed a high-fat diet than mice fed a normal diet, and higher inceptor expression was associated with a higher HOMA-IR index in the mice. ...

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