Inhibiting P2RY14 for inflammatory bowel disease

Inhibiting the purinergic receptor P2RY14 could help treat inflammatory bowel disease by preventing RIPK1-driven necroptosis of intestinal epithelial cells.

Bioinformatic analysis of public data sets identified higher P2RY14 expression in intestinal biopsies from ulcerative colitis patients than biopsies from healthy individuals. In colon samples, P2RY14 protein expression was higher for ulcerative colitis patients than healthy individuals, and higher P2RY14 expression was observed in patients’ intestinal epithelial cells than in their lamina propria cells. ...