Host SCGB1D2 for Lyme disease

Treatment with recombinant SCGB1D2, a host secretoglobin that forms ligand-binding dimers and is expressed by the skin and other secretory tissues, could help prevent infections caused by Borrelia burgdorferi, the causative agent of Lyme disease, by inhibiting bacterial growth.

A genome-wide association study on Lyme disease using genetic and epidemiologic data from FinnGen and Estonian Biobank identified a previously uncharacterized proline-to-leucine missense mutation in host SCGB1D2 that is associated with disease susceptibility. ...