Inhibiting ACSS2 for fibrotic kidney disease

Inhibiting the crotonyl-CoA-producing enzyme ACSS2 could help treat fibrotic kidney disease by decreasing H3K9 histone crotonylation-induced IL-1β production by tubular epithelial cells, and subsequent induction of tubular epithelial cell senescence and pathogenic macrophage phenotypes.

ACSS2 protein expression was higher in kidney samples from chronic kidney disease patients, and from mice with unilateral ureteric obstruction- or folic acid neuropathy-induced kidney fibrosis, than in samples from healthy individuals or control mice without fibrosis, respectively. ...