Inhibiting TREM1 for Alzheimer’s disease

Inhibiting expression of the myeloid receptor TREM1 in microglia could help treat Alzheimer’s disease by maintaining mitochondrial activity in neuronal synaptosomes.

In frontal cortex samples, the number of TREM1-positive microglia was higher surrounding amyloid plaques from Alzheimer’s patients than in samples from individuals without Alzheimer’s, or amyloid-free regions from Alzheimer’s patients. TREM1 protein expression was higher in the frontal cortex of demented Alzheimer’s Braak V-VI patients than non-demented Braak I-II patients, and higher TREM1 expression was associated with amyloid and tau pathology. A meta-analysis of previously published studies showed higher plasma soluble TREM1 levels were associated with Alzheimer's risk. ...