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ARTICLE | Distillery Therapeutics

Controlling SPHK1 and SPHK2 activity for heart failure

BC Staff
May 31, 2024 11:17 PM UTC

Inhibiting and enhancing the activities of the sphingolipid synthesis-related isoenzymes SPHK1 and SPHK2, respectively, could enhance cardiac regeneration by reducing SPHK1-induced cardiac fibrosis and promoting SPHK2-mediated cardiomyocyte proliferation.

In neonatal mouse models of non-regenerative cardiac injury, systemic SPHK1 deletion improved cardiac performance and repair capacity compared with normal expression. ...

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