Inhibiting FABP5 for hepatocellular carcinoma

Inhibiting the fatty acid binding protein FABP5 could help treat hepatocellular carcinoma (HCC) by promoting a pro-inflammatory tumor microenvironment via macrophage-driven CD8⁺ T cell infiltration, and increasing liver cancer cell death via lipid-peroxidation-induced ferroptosis.

A transcriptomic atlas for obesity-driven HCC was generated using single-cell RNA sequencing of hepatocytes from mice fed a choline-deficient high-fat diet for 15 months to induce HCC or a normal diet. Mice fed the diet for 15 months that had high serum levels of AFP were considered HCC-positive. ...