Activating ID3 in macrophages for anti-tumor immunity

Activating ID3, a lineage-determining nuclear factor on macrophages that decreases transcription of the phagocytosis-inhibiting receptor SIRPA, could help treat cancer by promoting phagocytosis of live tumor cells, and increasing proliferation and activation of NK and CD8⁺ T cells. 

In a mouse pancreatic cancer cell line co-cultured with primary mouse bone marrow-derived macrophages (BMDMs), lentiviral overexpression of ID3 in the macrophages increased phagocytosis of tumor cells compared with normal expression.  ...