LILRB4 inhibitory mAb for Alzheimer’s diseae

A mAb that inhibits signaling via the immunoglobulin-like receptor LILRB4 in microglia, and blocks its interaction with APOE, could help treat Alzheimer's by enhancing microglial activity while decreasing interferon signaling.

Microglial LILRB4 expression was higher in brain samples from Alzheimer’s patients than from non-Alzheimer's controls. ...