Inhibiting EPHA2 signaling for sepsis

Inhibiting the interaction between the receptor tyrosine kinase EPHA2 and its ligand EFNA1 could help treat sepsis by decreasing lung endothelial cell dysfunction.

EPHA2 and EFNA1 protein expression were higher in serum from pediatric septic patients than individuals without sepsis, and higher EPHA2 and EFNA1 expression levels were associated with higher levels of organ dysfunction and serum endothelial activation and dysfunction biomarkers. ...