Inhibiting transcription factor ETS2 for autoimmune diseases

Inhibiting the transcription factor ETS2, which is upregulated by autoimmune disease-associated SNPs in chromosome 21q22, could help treat these diseases by decreasing inflammatory pathway expression in macrophages.

In analyses of publicly available histone acetylation and chromatin structure data from primary human immune cells, a macrophage enhancer region was identified in the autoimmune disease-associated chromosomal region 21q22, and found to interact with the promoter of ETS2. In primary human monocytes, knockout of this enhancer region decreased inflammation-induced ETS2 expression...