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ARTICLE | Distillery Therapeutics

Inhibiting USP8 for cGAS-mediated autoimmune diseases

BC Staff
August 1, 2024 4:15 PM UTC

Inhibiting USP8, a stress-granule-localized deubiquitinase that promotes activation of the double-stranded DNA (dsDNA) sensor cGAS, could help treat cGAS-mediated autoimmune diseases by decreasing innate immune activation. 

In bioinformatic analyses of gene expression in peripheral blood mononuclear cells, USP8 mRNA expression was higher in patients with systemic lupus erythematosus (SLE) than healthy donors, and was associated with higher expression of an inflammation gene signature...

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