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ARTICLE | Distillery Therapeutics

PHD2 or PHD1 inhibition for AML

August 1, 2024 4:16 PM UTC

Inhibiting the HIF-prolyl hydroxylases PHD2 or PHD1 could help treat AML by stabilizing the transcription factor HIF1A and increasing expression of the pro-apoptotic factor BNIP3, without disrupting normal hematopoiesis.

In patient AML samples, higher PHD2 expression was associated with adverse AML prognosis. ...

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