PHD2 or PHD1 inhibition for AML
Inhibiting the HIF-prolyl hydroxylases PHD2 or PHD1 could help treat AML by stabilizing the transcription factor HIF1A and increasing expression of the pro-apoptotic factor BNIP3, without disrupting normal hematopoiesis.
In patient AML samples, higher PHD2 expression was associated with adverse AML prognosis. ...
BCIQ Target Profiles
Hypoxia-inducible factor prolyl hydroxylase 2 (EGLN1) (HIF-PH2) (PHD2)