APLN for muscular dystrophy

The peptide hormone APLN, which binds the receptor APLNR, could help treat muscular dystrophy by increasing endothelial cell secretion of extracellular vesicles and the soluble growth factor IGF-2, which promote muscle regeneration.

Bioinformatic analysis of public data sets identified APLNR as being more highly expressed in skeletal muscle endothelial cells from mice with chemically induced muscle injury than in similar cells from healthy controls. ...