Inhibiting non-canonical STING activity in neurons for MS

Inhibiting non-canonical neuronal activation of the endoplasmic reticulum innate immune regulator STING, which is triggered by glutamate excitotoxicity, could help treat MS by decreasing STING-induced autophagic degradation of the ferroptosis repressor GPX4, thus preventing neuronal death via ferroptosis.

STING protein expression was higher in cortical neurons of normal-appearing gray matter and inflamed cortices from progressive MS patients or relapsing-remitting MS patients, respectively, than in neurons from individuals without MS. ...