Peptide blockade of YTHDF3 palmitoylation for pancreatic cancer

A cell-penetrating peptide blocking palmitoylation of YTHDF3 — an RNA-binding protein that reads m6A modifications — by the enzyme ZDHHC20, which is induced downstream of mutant KRAS signaling, could help treat pancreatic cancer by decreasing MYC translation.

Bioinformatic analyses of public pancreatic cancer datasets identified higher mRNA and protein expression of ZDHHC20, a palmitoyl acyltransferase, in tumors than in normal adjacent pancreas tissue, and higher ZDHHC20 mRNA expression was associated with decreased overall survival. ...