Inhibiting DDX4 for cancer
Inhibiting DDX4, an RNA helicase that post-transcriptionally regulates RNA within cytoplasmic ribonucleoprotein granules and has normal functions in spermatids, could help treat DDX4-expressing cancers by decreasing tumor growth and invasion.
DDX4 protein expression was increased in breast cancer, colon cancer, lung cancer, fibrosarcoma, and leiomyosarcoma patient tumor samples compared with corresponding tissues from patients without cancer. ...
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