ANGPTL4 for sepsis-induced endothelial dysfunction

The glycoprotein ANGPTL4 could help treat sepsis-induced endothelial dysfunction by interacting via its N-terminus with the heparan sulfate proteoglycan SDC4 in microvessel endothelial cells, which promotes endothelial cell integrity.

In primary human endothelial cells exposed to Neisseria meningitidis, a bacteria that causes sepsis and meningitis, endothelial cell integrity was higher, and apoptosis was lower when cells were isolated from brain parenchymal microvessels than when they were isolated from derma microvessels. ...