Inhibiting tumor P2RY6 for antitumor immunity

Inhibiting the pyrimidinergic G protein-coupled receptor P2RY6 on tumor cells could help increase antitumor immunity by decreasing the synthesis of the prostaglandin PGE2, which promotes pro-tumor macrophage polarization and inhibits natural killer cell, T cell and dendritic cell activity.

Bioinformatic analyses of tumors from public pan-cancer patient datasets identified P2RY6 mRNA expression as increased in most tumor types compared with paired adjacent normal tissues, and high P2RY6 expression was correlated with shorter survival. ...