ARTICLE | Distillery Therapeutics
An ATP1A1 stabilizer for anxiety
October 7, 2024 5:29 PM UTC
A stabilizer for the transmembrane ATPase ATP1A1 that promotes its interaction with the ATP-gated ion channel P2RX7 in microglial membranes could help treat stress-induced anxiety by decreasing potassium efflux and downstream NLRP3-driven adoption of pathogenic microglial phenotypes that increase neuronal hyperexcitability and decrease neurogenesis.
ATP1A1 protein expression was lower in the microglial membranes of mice with physical stress-induced anxiety than in microglia from mice not subjected to stress. ...