TLR8 inhibition in erythroid cells for inherited non-hemolytic anemia
Inhibiting the innate immune single-stranded RNA sensor TLR8 could help treat inherited non-hemolytic anemia by preventing the disruption of erythropoietin signaling and apoptosis in erythroid cells.
Genetic and phenotypic studies of a male pediatric patient with non-hemolytic anemia and his family identified an X-linked gain-of-function mutation in TLR8...
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Chinese Academy of Medical Sciences and Peking Union Medical College
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