Inhibiting trained immunity for post-stroke heart failure

Inhibiting IL-1β-driven epigenetic remodeling in hematopoietic stem cells, or blocking monocyte recruitment via CCR2 or CCR5, could help treat post-stroke heart failure by preventing a persistent trained immunity response that drives cardiac fibrosis.

In hearts from three post-stroke patients, left ventricle fibrosis, expression of extracellular matrix remodeling genes, and recruitment-CCR2 expressing monocytes were all increased compared with non-stroke controls...