Inhibiting Factor XII for diabetic kidney disease

Inhibiting the protease Factor XII could help treat diabetic kidney disease by preventing interactions with its receptor uPAR and co-receptor CD29, and thus decreasing DNA damage and senescence in kidney tubular cells.

Factor XII expression was higher in kidney tubules and urine from diabetic kidney disease patients than from individuals without diabetic kidney disease, and higher Factor XII expression was positively correlated with higher diabetic kidney disease severity, albuminuria and serum cystatin C levels, and inversely correlated with estimated glomerular filtration rate, a measure of kidney function...