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ARTICLE | Distillery Therapeutics

LNP-delivered Cas13 targeting viral NS5 protein for Dengue fever

BC Staff
October 9, 2024 6:53 PM UTC

An LNP delivering Cas13 mRNA and a guide RNA targeting Dengue NS5 protein, a viral RNA-dependent RNA polymerase and RNA methyltransferase, could help treat Dengue fever.

Six guide RNAs were designed to target a region in NS5 that is conserved in Dengue serotypes 2 and 3, and these were tested in an in vitro cell-free detection assay to confirm targeting ability. ...

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