Inhibiting IgG or B cells for neuropathic pain

Inhibiting immunoglobin IgG production by B cells could help treat neuropathic pain by decreasing activation of its FCGR in sensory neurons, which decreases the neuronal hyperactivity that leads to allodynia.

IgG levels were higher in the lumbar dorsal root ganglia from chronic pain patients than from individuals without chronic pain. In bioinformatic analyses of public data sets, a B cell gene expression signature was higher in the dorsal root ganglia from neuropathic pain patients than from individuals without neuropathic pain. ...