T helper cells transiently expressing autoantigens for CNS injury

CD4⁺ T cells engineered to transiently express neuronal or myelin self antigens could help treat CNS injury by decreasing activation of microglia and injury site-infiltrating macrophages by inducing non-canonical anti-inflammatory IFNγ signaling.

Cell profiling studies in spinal cord injury patients and a mouse model of spinal cord injury showed clonal expansion of T cells at the site of injury. ...