Inhibiting IFNγ or fibroblast-driven inflammation and vasodilation for rosacea

Inhibiting IFNγ signaling or fibroblast activity could help treat rosacea by decreasing inflammation and abnormal vasodilation, and restoring expression of epidermal barrier genes, in rosacea skin lesions.

Single cell transcriptomic data from lesional and non-lesional facial skin of rosacea patients showed increased expression of IFNγ receptors and decreased expression of skin barrier pathway genes in CD74⁺ keratinocytes — an epithelial cell subpopulation enriched in the lesion skin of all rosacea patient subtypes — compared with individuals without rosacea. Expression of IFNγ in T cells, and of pro-inflammatory and vasodilative genes — such as the enzyme PTGDS — in fibroblasts, was higher for rosacea patients than for individuals without rosacea. ...