Inhibiting JAK-induced STAT1 signaling for toxic epidermal necrolysis

Inhibiting the JAK family of intracellular tyrosine kinases could help treat toxic epidermal necrolysis by preventing downstream activation of the transcription factor STAT1 and subsequent type I and type II interferon signaling in keratinocytes, which decreases cell death and epidermal detachment.

Proteomic analysis identified higher STAT1 expression in skin keratinocytes and immune cells from toxic epidermal necrolysis patients than in the same cells from individuals without toxic epidermal necrolysis. STAT1 activation, as assessed by histological staining for phosphorylation, was higher in skin keratinocytes and immune cells from toxic epidermal necrolysis patients than in the same cells from individuals without toxic epidermal necrolysis. ...