Sprayable nanorods delivering inflammasome inhibitors for psoriasis

Topical delivery of inflammasome inhibitors via sprayable rod-shaped lipid nanoparticles that mimic bacteria could help treat psoriasis by enhancing binding and internalization of the compounds by macrophages, and limiting systemic effects.

In a human bone marrow-derived macrophage cell line exposed to the inflammatory stimulus LPS, nanorods composed of the inflammasome-inhibiting lipid pyridoxine dipalmitate and carboxylic acid in a 10:1 ratio decreased signs of inflammation, including expression of the pattern recognition receptor TLR4 and the cytokine IL-1β, compared with nanoparticles with lipid ratios of 2:1 (spheres) and 5:1 (ellipses). ...