Increasing N-acetyltaurine levels for obesity

Increasing levels of the taurine metabolite N-acetyltaurine via supplementation or by inhibiting PTER, an N-acetyltaurine hydrolase whose function was previously unknown, could help treat obesity by increasing activation of the GDF15 receptor GFRAL in the brainstem, which decreases food intake and body fat mass without decreasing lean mass.

In primary mouse kidney and liver homogenates exposed to N-acetyltaurine, PTER was identified as an N-acetyltaurine hydrolase. ...