Increasing lung MFSD7C levels for hemolytic anemia

Increasing levels of the membrane transport protein MFSD7C could help treat hemolytic anemia by preventing lung endothelial cell and alveolar macrophage death via ferroptosis, reducing inflammation and fibrosis.

In a human lung endothelial cell line, exposure to heme to induce a hemolytic anemia phenotype decreased MFSD7C protein expression compared with vehicle. ...