Inhibiting LGALS1 for myelofibrosis

Inhibiting the β-galactoside-binding protein LGALS1 could help treat myelofibrosis by decreasing myeloproliferation and fibrosis in the bone marrow.

A transcriptomic atlas for myelofibrotic bone marrow was generated via comparative single-cell RNA sequencing of bone marrow from mice with genetically induced myelofibrosis and healthy controls. Bioinformatic analysis of data from the atlas identified higher LGALS1 expression in basophils, mast cells, mesenchymal stromal cells, and megakaryocytes in bone marrow from mice with myelofibrosis than in bone marrow from healthy controls. ...