CAR Tregs targeting OX40L for GvHD
CAR Treg cells targeting OX40L, a T cell-activating costimulatory signal upregulated in GvHD, could help treat GVHD by suppressing alloreactive T effector cells.
A CAR construct that combined a single-chain variable fragment targeting human OX40L with intracellular CD28 costimulatory and CD3 signaling domains was transduced into activated human Treg cells to generate OX40L-targeting CAR T reg cells...
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