METTL3 for inflammatory skin diseases

Increasing activity of the methyltransferase METTL3, which adds N(6)-methyladenosine (m6A) modifications onto RNA, could help treat inflammatory skin diseases by stabilizing the mRNA of the fatty acid elongase ELOVL6, which reduces palmitic acid accumulation in the skin, thus decreasing inflammatory neutrophil recruitment.

METTL3 mRNA and protein expression, as well as global cellular levels of m6A modifications on mRNA, were lower in skin lesion samples from psoriasis or atopic dermatitis patients than in non-lesional skin from healthy individuals. In bioinformatic analysis of public data sets, METTL3 expression was lower in skin lesions from psoriasis or atopic dermatitis patients than in non-lesional skin from healthy individuals. ...